so it is with schizophrenia

“… as we know, there are known knowns; there are things we know we know. We also know there are known unknowns; that is to say we know there are some things we do not know. But there are also unknown unknowns – the ones we don’t know we don’t know.”

Donald Rumsfeld, United States Secretary of Defense, Department of Defense news briefing, 2002

brain changes at schizophrenia onset

At the age of the onset of illness hippocampus volume is reduced , hippocampal neurogenesis is reduced, cognitive impairment of memory management stops sufferers ‘moving on’, the lateral ventricle is enlarged and stays that way throughout the illness