so it is with schizophrenia

“… as we know, there are known knowns; there are things we know we know. We also know there are known unknowns; that is to say we know there are some things we do not know. But there are also unknown unknowns – the ones we don’t know we don’t know.”

Donald Rumsfeld, United States Secretary of Defense, Department of Defense news briefing, 2002

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brain changes at schizophrenia onset

At the age of the onset of illness hippocampus volume is reduced , hippocampal neurogenesis is reduced, cognitive impairment of memory management stops sufferers ‘moving on’, the lateral ventricle is enlarged and stays that way throughout the illness